“Unexpected Antitumorigenic Effect of Fenbedazole when combined with supplementary Vitamins”

Cancer is one of the leading causes of death worldwide, accounting for approximately 10 million deaths annually. Chemotherapy and radiation therapy are the standard cancer treatments, but they often have severe side effects and can be ineffective in some cases.

Therefore, researchers are continuously exploring alternative treatments to combat this deadly disease. Recently, a surprising antitumor effect has been discovered in a common veterinary drug, fenbendazole, when combined with supplementary vitamins. Fenbendazole is a broad-spectrum anthelmintic drug commonly used in veterinary medicine to treat parasitic infections in livestock, dogs, and cats.

The drug works by disrupting the metabolism of the parasite, leading to its death. However, a study conducted by Dr. T. Simoncini, an Italian oncologist, revealed that fenbendazole has an antitumor effect in cancer cells. Dr. Simoncini’s study showed that fenbendazole was effective against various types of cancer cells, including melanoma, lung cancer, colon cancer, and breast cancer.

The mechanism behind the antitumor effect of fenbendazole is not entirely understood. However, it is believed that the drug disrupts the glucose uptake of cancer cells, which starves them of their energy source, leading to their death. Moreover, fenbendazole has also been shown to activate the immune system, which can help the body fight cancer.

In a recent study, Dr. Akash Patnaik, an oncologist at the University of Chicago, discovered that combining fenbendazole with supplementary vitamins resulted in a more significant antitumor effect. Dr. Patnaik’s team tested the combination therapy on mice with prostate cancer, and the results were remarkable. The combination therapy resulted in a reduction in tumor size, increased survival rates, and no signs of toxicity or adverse side effects.

The supplementary vitamins used in the study included vitamin E, vitamin C, and vitamin B12. Vitamin E is a potent antioxidant that helps protect cells from damage. Vitamin C is essential for the production of collagen, a protein that helps maintain healthy skin, bones, and cartilage. Vitamin B12 is necessary for proper nerve function and red blood cell production. The combination of fenbendazole with these vitamins seems to enhance the drug’s antitumor effect.

It is important to note that fenbendazole is not a cure for cancer, and further research is needed to determine its efficacy in humans. However, the discovery of its antitumor effect is promising, and the addition of supplementary vitamins may further enhance its therapeutic potential. Fenbendazole is an anti-helminthic drug used in the treatment of gastroenteritis and intestinal roundworms in animals.

It is also used as a treatment for some types of cancer. It can be given by mouth or injection into a vein or muscle. Side effects include diarrhea, vomiting, loss of appetite, and weight loss. In dogs, it can cause an allergic reaction known as pruritus (itching). Fenbendazole is sometimes used together with piperazine.

Fenbendazole was patented in 1969 and approved for use in the United States in 1986. It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. In conclusion, the unexpected antitumor effect of fenbendazole when combined with supplementary vitamins is an exciting development in cancer research. The drug’s broad-spectrum activity against various types of cancer cells, coupled with its low toxicity and affordability, make it an attractive option for further investigation. While more research is needed, the combination therapy’s efficacy in preclinical studies is promising and offers hope

Citations

• Cats.com, D. V. M., & Dr. Chris Vanderhoof, D. V. M. (2022, September 8). Fenbendazole for cats: Overview, dosage & side effects. Cats.com. Retrieved March 23, 2023, from https://cats.com/fenbendazole-for-cats

• Suter, C., et al. “Prevention and treatment of Encephalitozoon cuniculi infection in rabbits with fenbendazole.” Veterinary Record 148.15 (2001): 478-480.

• Duan, Qiwen, Yanfeng Liu, and Sara Rockwell. “Fenbendazole as a potential anticancer drug.” Anticancer Research 33.2 (2013): 355-362. • Aycock-Williams, A., Pham, L., Liang, M., Adisetiyo, H.A., Geary, L.A., Cohen, M.B., Casebolt, D.B. and Roy-Burman, P., 2011. Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells. J Cancer Res Exp Oncol, 3(9), pp.115-121. • Gao P, Dang CV, Watson J. Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. Journal of the American Association for Laboratory Animal Science. 2008 Nov 1;47(6):37-40.

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